Molecular weight (DA)
69kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 410-490
Specificity
NBPF3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
neuroblastoma breakpoint family member 3(NBPF3) Homo sapiens This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene fami
Function
miscellaneous:Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.,similarity:Belongs to the NBPF family.,similarity:Contains 5 NBPF domains.,tissue specificity:Expressed in testis and fetal heart, as well as in non small cell lung carcinoma and neuroblastoma cell line.,
Protein name
Neuroblastoma breakpoint family member 3 (Protein AE2) (Protein SHIIIa4)
Human protein sequence Database
Q9H094
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Expressed in testis and fetal heart, as well as in non small cell lung carcinoma and neuroblastoma cell line.
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