Molecular weight (DA)
58kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 20-100
Specificity
NETO1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
Function
function:May play a role in the development and/or maintenance of neuronal circuitry.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 2 CUB domains.,tissue specificity:Isoform 1 and isoform 2 are retina-specific whereas isoform 3 is found in retina as well as at lower levels in adult and fetal brain.,
Protein name
Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1)
Human protein sequence Database
Q8TDF5
Mouse protein sequence database
Q8R4I7
Rat protein sequence database
Cellular localization
[Isoform 2]: Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, postsynaptic density membrane . Component of the postsynaptic density (PSD) of excitatory synapses. .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 1]: Secreted .
Tissue expression
Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.
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