Molecular weight (DA)
101kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 600-680
Specificity
NU107 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
nucleoporin 107(NUP107) Homo sapiens This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
Function
function:Essential component of nuclear pore complex. Required for the assembly of peripheral proteins into the nuclear pore complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the nucleoporin Nup84/Nup107 family.,subcellular location:Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.,subunit:Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus.,
Protein name
Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)
Fields
>>Nucleocytoplasmic transport;>>Amyotrophic lateral sclerosis
Human protein sequence Database
P57740
Mouse protein sequence database
Q8BH74
Rat protein sequence database
P52590
Cellular localization
Nucleus membrane . Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755). .
Tissue expression
Ubiquitously expressed in fetal and adult tissues.
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