Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 300-380
Specificity
TPTE2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002],
Function
catalytic activity:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,tissue specificity:Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.,
Protein name
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)
Human protein sequence Database
Q6XPS3
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Isoform 3]: Endoplasmic reticulum membrane ; Multi-pass membrane protein .; [Isoform 1]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .; [Isoform 4]: Cytoplasm .
Tissue expression
Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
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