Molecular weight (DA)
24kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Specificity
PLS2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
Function
cofactor:Calcium.,function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.,online information:Scramblase entry,similarity:Belongs to the phospholipid scramblase family.,tissue specificity:Exclusively expressed in testis.,
Protein name
Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2)
Human protein sequence Database
Q9NRY7
Mouse protein sequence database
Q9DCW2
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type II membrane protein .; [Isoform 1]: Nucleus .
Tissue expression
Expression of isoform 1 seems restricted to testis.
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