Molecular weight (DA)
54kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 180-260
Specificity
PLTP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Converts HDL into larger and smaller particles. May play a key role in extracellular phospholipid transport and modulation of hdl particles.,similarity:Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.,tissue specificity:Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.,
Protein name
Phospholipid transfer protein (Lipid transfer protein II)
Fields
>>PPAR signaling pathway;>>Cholesterol metabolism
Human protein sequence Database
P55058
Mouse protein sequence database
P55065
Rat protein sequence database
Cellular localization
Secreted . Nucleus . Nuclear export is XPO1/CRM1-dependent. .
Tissue expression
Widely expressed. Highest level of expression in the ovary, thymus and placenta, with moderate levels found in the pancreas, small intestine, testis, lung and prostrate. Low level expression in the kidney, liver and spleen, with very low levels found in the heart, colon, skeletal muscle, leukocytes and brain. Expressed in the cortical neurons.
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