Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 150-230
Specificity
HCN3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
Function
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.,
Protein name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Human protein sequence Database
Q9P1Z3
Mouse protein sequence database
O88705
Rat protein sequence database
Q9JKA8
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in brain.
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