Molecular weight (DA)
16kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Specificity
UBE2W Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
Function
catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Homodimer.,
Protein name
Ubiquitin-conjugating enzyme E2 W (EC 6.3.2.19) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Fields
>>Ubiquitin mediated proteolysis
Human protein sequence Database
Q96B02
Mouse protein sequence database
Q8VDW4
Rat protein sequence database
B5DEI4
Cellular localization
Nucleus . In the nucleus, colocalizes with FANCL. .
Tissue expression
Widely expressed, with highest expression in brain, liver, pancreas and heart.
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