Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Specificity
PPR3D Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. [provided by RefSeq, Jul 2008],
Function
domain:The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.,function:Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.,similarity:Contains 1 CBM21 (carbohydrate binding type-21) domain.,subunit:Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.,tissue specificity:Expressed in all tissue tested. High expression in skeletal muscle and heart.,
Protein name
Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6)
Fields
>>Insulin signaling pathway;>>Insulin resistance
Human protein sequence Database
O95685
Mouse protein sequence database
Rat protein sequence database
Cellular localization
glycogen granule,intracellular membrane-bounded organelle,
Tissue expression
Expressed in all tissues tested. High expression in skeletal muscle and heart.
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