Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 220-300
Specificity
PPME1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012],
Function
function:Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro).,sequence caution:Wrong choice of CDS.,similarity:Belongs to the AB hydrolase superfamily.,subunit:Binds PPP2CB.,
Gene Name
PPME1 PME1 PP2593 PRO0750
Protein name
Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)
Human protein sequence Database
Q9Y570
Mouse protein sequence database
Q8BVQ5
Rat protein sequence database
Q4FZT2
Cellular localization
cell-cell adherens junction,
Tissue expression
Amygdala,Cervix carcinoma,Fetal liver,Lung,Platelet,Skin,
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