Molecular weight (DA)
22kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
RANG Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
function:Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.,similarity:Belongs to the RANBP1 family.,similarity:Contains 1 RanBD1 domain.,
Protein name
Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)
Fields
>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
Human protein sequence Database
P43487
Mouse protein sequence database
P34022
Rat protein sequence database
Cellular localization
intracellular,nucleus,nuclear envelope,cytoplasm,centrosome,cell-cell adherens junction,axon cytoplasm,
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