Molecular weight (DA)
165kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Specificity
RHG05 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of p120GAP.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 4 FF domains.,subcellular location:Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.,tissue specificity:Expressed in kidney, brain, liver and lung.,
Gene Name
ARHGAP5 RHOGAP5
Protein name
Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)
Fields
>>Focal adhesion;>>Leukocyte transendothelial migration
Human protein sequence Database
Q13017
Mouse protein sequence database
P97393
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane ; Peripheral membrane protein . Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. .
Tissue expression
Detected in skin fibroblasts (at protein level) (PubMed:8537347).
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