Molecular weight (DA)
155kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1120-1200
Specificity
RRBP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012],
Function
alternative products:Additional isoforms seem to exist. Additional isoforms are probable deriving from alternative splicing in the repeat region,function:Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.,
Protein name
Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q9P2E9
Mouse protein sequence database
Q99PL5
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
Tissue expression
Brain,Epithelium,Pancreas,Uterus,
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