57kD

Synthesized peptide derived from human protein . at AA range: 230-310

NLK Polyclonal Antibody detects endogenous levels of protein.

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

WB 1:500-2000 ELISA 1:5000-20000

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin.,function:Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.,PTM:Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly nuclear. A smaller fraction is cytoplasmic.,subunit:Interacts with STAT3 (By similarity). Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB.,

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin.,function:Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.,PTM:Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contain

NLK LAK1

Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)

NLK

>>MAPK signaling pathway;>>FoxO signaling pathway;>>Wnt signaling pathway;>>Adherens junction

51701

Q9UBE8

O54949

D3ZSZ3

Nucleus . Cytoplasm . Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). .

Amygdala,Placenta,T-cell,Uterus,

-20°C/1 year