Molecular weight (DA)
103kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PP1RA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012],
Function
function:Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.,PTM:Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA.,similarity:Contains 1 C3H1-type zinc finger.,similarity:Contains 1 TFIIS N-terminal domain.,subcellular location:Found in discrete nucleoplasmic bodies and within nucleoli.,subunit:Interacts with PPP1CA and PPP1CC.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
Gene Name
PPP1R10 CAT53 FB19 PNUTS
Protein name
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (
Human protein sequence Database
Q96QC0
Mouse protein sequence database
Q80W00
Rat protein sequence database
O55000
Cellular localization
Nucleus . Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). .
Tissue expression
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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