Molecular weight (DA)
114kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 900-980
Specificity
DGLA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010],
Function
cofactor:Calcium.,enzyme regulation:Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.,function:Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,tissue specificity:Highly expressed in brain and pancreas.,
Gene Name
DAGLA C11orf11 KIAA0659 NSDDR
Protein name
Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator)
Fields
>>Retrograde endocannabinoid signaling;>>Aldosterone synthesis and secretion
Human protein sequence Database
Q9Y4D2
Mouse protein sequence database
Q6WQJ1
Rat protein sequence database
Q5YLM1
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Cell projection, dendritic spine membrane ; Multi-pass membrane protein . Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. .
Tissue expression
Highly expressed in brain and pancreas.
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