Molecular weight (DA)
215kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TCF20 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Function
domain:The atypical PHD domain functions as a negative modulator of cofactor binding.,function:Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 A.T hook DNA-binding domain.,similarity:Contains 1 PHD-type zinc finger.,subunit:Homodimer (Probable). Interacts with RNF4 and JUN.,tissue specificity:Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.,
Gene Name
TCF20 KIAA0292 SPBP
Protein name
Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)
Human protein sequence Database
Q9UGU0
Mouse protein sequence database
Q9EPQ8
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
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