Molecular weight (DA)
74kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TCF25 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008],
Function
domain:The C-terminal region mediates transcriptional repression.,function:May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.,similarity:Belongs to the TCF25 family.,subcellular location:Some staining in the cytosol.,subunit:Interacts with XIAP.,tissue specificity:In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.,
Gene Name
TCF25 KIAA1049 NULP1 FKSG26
Protein name
Transcription factor 25 (TCF-25) (Nuclear localized protein 1)
Human protein sequence Database
Q9BQ70
Mouse protein sequence database
Q8R3L2
Rat protein sequence database
Cellular localization
Nucleus . Some staining in the cytosol.
Tissue expression
In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.
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