Molecular weight (DA)
17kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TNNC2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008],
Function
function:Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.,miscellaneous:Skeletal muscle troponin C binds four calcium ions.,similarity:Belongs to the troponin C family.,similarity:Contains 4 EF-hand domains.,
Protein name
Troponin C, skeletal muscle
Fields
>>Calcium signaling pathway
Human protein sequence Database
P02585
Mouse protein sequence database
P20801
Rat protein sequence database
Cellular localization
cytosol,troponin complex,
Tissue expression
Liver,Muscle,Skeletal muscle,Tongue,
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