Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PTN12 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoform
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in PTPN12 are found in some colon cancers.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.,
Protein name
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Human protein sequence Database
Q05209
Mouse protein sequence database
P35831
Rat protein sequence database
Cellular localization
Cytoplasm . Cell junction, focal adhesion . Cell projection, podosome . Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. .
Tissue expression
Brain,Cerebellum,Colon,Colorectal carcinoma,Epithel
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