Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PTN9 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,
Protein name
Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)
Human protein sequence Database
P43378
Mouse protein sequence database
O35239
Rat protein sequence database
Q641Z2
Cellular localization
Cytoplasm .
Tissue expression
Brain,Pancreas,Placenta,
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