Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
UBXN4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008],
Function
domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).,
Gene Name
UBXN4 KIAA0242 UBXD2 UBXDC1
Protein name
UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q92575
Mouse protein sequence database
Q8VCH8
Rat protein sequence database
Q5HZY0
Cellular localization
Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. .
Tissue expression
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
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