Molecular weight (DA)
377kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
UTRO Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008],
Function
function:May play a role in anchoring the cytoskeleton to the plasma membrane.,online information:Utrophin entry,similarity:Contains 1 WW domain.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 20 spectrin repeats.,subcellular location:Neuromuscular junction.,subunit:Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM.,tissue specificity:Muscle.,
Protein name
Utrophin (Dystrophin-related protein 1) (DRP-1)
Human protein sequence Database
P46939
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Neuromuscular junction.
Tissue expression
Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney.
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