Molecular weight (DA)
31kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
VDAC3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
Function
domain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.,function:Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.,similarity:Belongs to the eukaryotic mitochondrial porin family.,tissue specificity:Widely expressed. Highest in testis.,
Protein name
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)
Fields
>>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Ferroptosis;>>Necroptosis;>>Cellular senescence;>>Neutrophil extracellular trap formation;>>NOD-like receptor signaling pathway;>>Cholesterol metabolism;>>Alzheimer disease;>>Parkinson disease;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Hepatitis B;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy
Human protein sequence Database
Q9Y277
Mouse protein sequence database
Q60931
Rat protein sequence database
Q9R1Z0
Cellular localization
Mitochondrion outer membrane . Membrane . May localize to non-mitochondrial membranes. .
Tissue expression
Expressed in erythrocytes (at protein level) (PubMed:27641616). Widely expressed. Highest in testis (PubMed:9781040).
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