Molecular weight (DA)
100kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
WDR44 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Function
function:Downstream effector for RAB11. May be involved in vesicle recycling.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 7 WD repeats.,subcellular location:Colocalized with RAB11 along microtubules oriented toward lamellipodia.,subunit:Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins.,
Protein name
WD repeat-containing protein 44 (Rabphilin-11)
Human protein sequence Database
Q5JSH3
Mouse protein sequence database
Q6NVE8
Rat protein sequence database
Q9R037
Cellular localization
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Colocalized with RAB11 along microtubules oriented toward lamellipodia. .
Tissue expression
Amygdala,Colon endothelium,Endometrial tumor,Epithelium,Teratocarcinoma,Testis,Tong
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