Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ZHX3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008],
Function
function:Acts as a transcriptional repressor. Is a regulator of podocyte gene expression during primary glomerula disease.,similarity:Belongs to the ZHX family.,similarity:Contains 2 C2H2-type zinc fingers.,similarity:Contains 5 homeobox DNA-binding domains.,subunit:Forms homodimers. Also forms heterodimers with ZHX1 and ZHX2. Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.,tissue specificity:Widely expressed. High expression in kidney.,
Gene Name
ZHX3 KIAA0395 TIX1
Protein name
Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)
Human protein sequence Database
Q9H4I2
Mouse protein sequence database
Q8C0Q2
Rat protein sequence database
Q80Z36
Cellular localization
Nucleus .
Tissue expression
Widely expressed. High expression in kidney. Expressed during osteogenic differentiation.
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