Molecular weight (DA)
63kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
CCNK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008],
Function
function:May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9.,tissue specificity:Ubiquitously expressed. Highest levels in testis.,
Human protein sequence Database
O75909
Mouse protein sequence database
O88874
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Widely expressed. Highest levels in testis.
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