Molecular weight (DA)
27kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
FA58A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
Function
disease:Defects in FAM58A are the cause of toe syndactyly, telecanthus, and anogenital and renal malformations (STAR) [MIM:300707]; also known as STAR syndrome or syndactyly with renal and anogenital malformations.,function:May have a role in cell proliferation.,similarity:Belongs to the cyclin family. Cyclin-like FAM58 subfamily.,subunit:Interacts with SALL1.,
Protein name
Cyclin-related protein FAM58A (Cyclin-M)
Human protein sequence Database
Q8N1B3
Mouse protein sequence database
Q8QZR8
Rat protein sequence database
Q4QQW5
Cellular localization
cyclin-dependent protein kinase holoenzyme complex,nucleus,
Tissue expression
B-cell,Blood,Kidney,Lung,
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