Molecular weight (DA)
13kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
LTOR3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011],
Function
function:Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPK2.,similarity:Belongs to the MAPKSP1 family.,subunit:Interacts with MAP2K1 and MAPK2. Interacts with MORG1 (By similarity). Heterodimer with MAPBPIP.,
Gene Name
LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783
Protein name
Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mito
Fields
>>MAPK signaling pathway;>>mTOR signaling pathway
Human protein sequence Database
Q9UHA4
Mouse protein sequence database
O88653
Rat protein sequence database
Q5U204
Cellular localization
Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Brain,Dendritic cell,Fetal liver,Liver,Lung
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