Molecular weight (DA)
51kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MINA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008],
Function
function:Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.,induction:Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.,sequence caution:Translated as Trp.,similarity:Belongs to the MINA53/NO66 family.,similarity:Contains 1 JmjC domain.,tissue specificity:Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.,
Gene Name
MINA MDIG MINA53 NO52
Protein name
MYC-induced nuclear antigen (Mineral dust-induced gene protein) (Nucleolar protein 52)
Human protein sequence Database
Q8IUF8
Mouse protein sequence database
Q8CD15
Rat protein sequence database
Q8CFC1
Cellular localization
Nucleus . Nucleus, nucleolus .
Tissue expression
Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.
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