Molecular weight (DA)
31kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 100-180
Specificity
HEXI2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
Function
domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).,similarity:Belongs to the HEXIM family.,subunit:Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.,tissue specificity:Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.,
Protein name
Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)
Human protein sequence Database
Q96MH2
Mouse protein sequence database
Q3TVI4
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
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