Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 170-250
Specificity
DIRC2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008],
Function
disease:A chromosomal aberration involving DIRC2 is found in familial renal cell carcinoma 1 (RCC1) [MIM:144700]. Translocation t(2;3)(q35;q21).,similarity:Belongs to the major facilitator superfamily.,tissue specificity:Ubiquitous. Expressed in proximal tubular cells of the kidney.,
Protein name
Disrupted in renal carcinoma protein 2 (Disrupted in renal cancer protein 2)
Human protein sequence Database
Q96SL1
Mouse protein sequence database
Q8BFQ6
Rat protein sequence database
Q66H95
Cellular localization
Lysosome membrane ; Multi-pass membrane protein .
Tissue expression
Ubiquitous. Expressed in proximal tubular cells of the kidney.
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