Molecular weight (DA)
124kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 830-910
Specificity
GRIP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glutamate receptor interacting protein 1(GRIP1) Homo sapiens This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010],
Function
domain:PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR.,function:May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.,similarity:Contains 7 PDZ (DHR) domains.,subcellular location:Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic ret
Protein name
Glutamate receptor-interacting protein 1 (GRIP-1)
Human protein sequence Database
Q9Y3R0
Mouse protein sequence database
Q925T6
Rat protein sequence database
P97879
Cellular localization
Cytoplasmic vesicle . Perikaryon . Cell projection, dendrite . Cytoplasm . Endomembrane system ; Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, postsynaptic density . Endoplasmic reticulum membrane ; Peripheral membrane protein . Membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities. .
Tissue expression
Fetal brain,PCR rescued clones,
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