Molecular weight (DA)
169kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
KDM5D Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
Function
alternative products:Additional isoforms seem to exist,cofactor:Ascorbate.,cofactor:Fe(2+).,domain:The JmjC domain is required for enzymatic activity.,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Interacts with PCGF6.,
Gene Name
KDM5D HY HYA JARID1D KIAA0234 SMCY
Protein name
Lysine-specific demethylase 5D (EC 1.14.11.-) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY)
Human protein sequence Database
Q9BY66
Mouse protein sequence database
Q62240
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expression is highly down-regulated in metastatic prostate tumors.
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