Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CP4FC Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cytochrome P450 family 4 subfamily F member 12(CYP4F12) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],
Function
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Expressed in small intestine, liver, colon and heart.,
Gene Name
CYP4F12 UNQ568/PRO1129
Protein name
Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)
Human protein sequence Database
Q9HCS2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane . Microsome membrane .
Tissue expression
Expressed in small intestine, liver, colon and heart.
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