Molecular weight (DA)
125kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
NGAP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
Function
function:Inhibitory regulator of the Ras-cyclic AMP pathway.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,
Protein name
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Fields
>>Ras signaling pathway
Human protein sequence Database
Q9UJF2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
cytoplasm,cytosol,intrinsic component of the cytoplasmic side of the plasma membrane,
Tissue expression
Brain,Epithelium,Heart,Muscle,PCR rescued clones,Peripheral Nervous System,
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