Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RASEF Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012],
Function
function:Binds predominantly GDP, and also GTP.,similarity:Belongs to the small GTPase superfamily. Rab family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer.,tissue specificity:Down-regulated in cutaneous melanoma cells but not in breast cancer cells.,
Protein name
Ras and EF-hand domain-containing protein (Ras-related protein Rab-45)
Human protein sequence Database
Q8IZ41
Mouse protein sequence database
Q5RI75
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region .
Tissue expression
Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
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