Molecular weight (DA)
37kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TRIB2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009],
Function
function:Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.,miscellaneous:Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:May associate with the cytoskeleton.,tissue specificity:Highly expressed in peripheral blood leukocytes.,
Protein name
Tribbles homolog 2 (TRB-2)
Human protein sequence Database
Q92519
Mouse protein sequence database
Q8K4K3
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . May associate with the cytoskeleton. .
Tissue expression
Highly expressed in peripheral blood leukocytes.
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