Molecular weight (DA)
58kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SPIT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
domain:This inhibitor contains two inhibitory domains.,function:Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MANSC domain.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,
Gene Name
SPINT1 HAI1 UNQ223/PRO256
Protein name
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)
Fields
>>Transcriptional misregulation in cancer;>>Prostate cancer
Human protein sequence Database
O43278
Mouse protein sequence database
Q9R097
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Colon,Milk,Placenta,
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