Molecular weight (DA)
66kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CHLE Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016],
Function
catalytic activity:An acylcholine + H(2)O = choline + a carboxylate.,disease:Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.,miscellaneous:Cholinesterase is highly reactive with organophosphate esters.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Homotetramer. The tetramer is composed of two dimers. The two subunits in a dimer are linked by a disulfide bond.,tissue specificity:Pr
Protein name
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)
Human protein sequence Database
P06276
Mouse protein sequence database
Q03311
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
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