Molecular weight (DA)
39kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SKAP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008],
Function
domain:The SH3 domain interacts with FYB.,function:Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.,PTM:Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC.,similarity:Belongs to the SKAP family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subcellular location:Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.,subunit:Homodimer. Interacts with FYN and PTPRC. Interacts with GRB2 when phosphorylated on Tyr-271. Interacts with F
Gene Name
SKAP1 SCAP1 SKAP55
Protein name
Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
Fields
>>Rap1 signaling pathway
Human protein sequence Database
Q86WV1
Mouse protein sequence database
Q3UUV5
Rat protein sequence database
Q4V7G1
Cellular localization
Cytoplasm . Nucleus . Cell membrane . Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. .
Tissue expression
Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
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