Molecular weight (DA)
45kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
FKBP8 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-58 is the initiator.,cofactor:Calcium.,function:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.,miscellaneous:Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.,sequence caution:The first part of the cDNA maps to the same locus, but in opposite orientation.,similarity:Contains 1 PPIase FKBP-type domain.,similarity:Contains 3 TPR repeats.,subunit:Homomultimers or heteromultimers (Potential). Forms heterodime
Protein name
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Human protein sequence Database
Q14318
Mouse protein sequence database
O35465
Rat protein sequence database
Q3B7U9
Cellular localization
Mitochondrion . Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; [Isoform 1]: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; [Isoform 3]: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .
Tissue expression
Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
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