Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DNER Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.,similarity:Contains 1 follistatin-like domain.,similarity:Contains 10 EGF-like domains.,subcellular location:Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.,subunit:Interacts with AP1G1. Interacts with NOTCH1.,tissue specificity:Expressed in brain, spinal cord and adrenal gland.,
Function
function:Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.,similarity:Contains 1 follistatin-like domain.,similarity:Contains 10 EGF-like domains.,subcellular location:Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.,subunit:Interacts with AP1G1. Interacts with NOTCH1.,tissue specificity:Expressed in brain, spinal cord and adrenal gland.,
Gene Name
DNER BET UNQ262/PRO299
Protein name
Delta and Notch-like epidermal growth factor-related receptor
Human protein sequence Database
Q8NFT8
Mouse protein sequence database
Q8JZM4
Rat protein sequence database
Cellular localization
Cell membrane; Single-pass type I membrane protein. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). .
Tissue expression
Expressed in brain, spinal cord and adrenal gland.
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