Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MFGM Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Function
function:Medin is the main constituent of aortic medial amyloid.,function:Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.,PTM:Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 2 F5/8 type C domains.,similarity:Contains 3 F5/8 type C domains.,tissue specificity:Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.,
Protein name
Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]
Human protein sequence Database
Q08431
Mouse protein sequence database
P21956
Rat protein sequence database
P70490
Cellular localization
Membrane ; Peripheral membrane protein . Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Peripheral membrane protein . Located in the acrosomal region of zona-pellucida bound sperm. .
Tissue expression
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
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