Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
KREM1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008],
Function
function:Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling.,similarity:Contains 1 CUB domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 WSC domain.,
Gene Name
KREMEN1 KREMEN KRM1
Protein name
Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose)
Human protein sequence Database
Q96MU8
Mouse protein sequence database
Q99N43
Rat protein sequence database
Q924S4
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
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