Molecular weight (DA)
28kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DKK2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008],
Function
function:Inhibitor of Wnt signaling pathway .,PTM:May be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in heart, brain, skeletal muscle and lung.,
Gene Name
DKK2 UNQ682/PRO1316
Protein name
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)
Fields
>>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q9UBU2
Mouse protein sequence database
Q9QYZ8
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in heart, brain, skeletal muscle and lung.
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