Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
EDN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],
Function
function:Endothelins are endothelium-derived vasoconstrictor peptides.,similarity:Belongs to the endothelin/sarafotoxin family.,tissue specificity:Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.,
Protein name
Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction;>>Renin secretion
Human protein sequence Database
P20800
Mouse protein sequence database
P22389
Rat protein sequence database
P23943
Cellular localization
Secreted.
Tissue expression
Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.
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