Molecular weight (DA)
43kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CYH1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Function
function:Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subunit:Interacts with TRIM23 and CYTIP.,tissue specificity:Ubiquitous.,
Gene Name
CYTH1 D17S811E PSCD1
Protein name
Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)
Fields
>>Phospholipase D signaling pathway;>>Endocytosis;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection
Human protein sequence Database
Q15438
Mouse protein sequence database
Q9QX11
Rat protein sequence database
P97694
Cellular localization
Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cell junction, tight junction . Cell junction, adherens junction . Colocalized with TJP1 during epithelial polarization. .
Tissue expression
Ubiquitous.
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