Molecular weight (DA)
279kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TLN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008],
Function
function:As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.,similarity:Contains 1 FERM domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Focal adhesion plaques and synapses.,subunit:Interacts directly with PIP5K1C.,
Fields
>>Rap1 signaling pathway;>>Focal adhesion;>>Platelet activation;>>Shigellosis;>>Human T-cell leukemia virus 1 infection
Human protein sequence Database
Q9Y4G6
Mouse protein sequence database
Q71LX4
Rat protein sequence database
Cellular localization
Cytoplasm . Cell junction, focal adhesion . Cell junction, synapse . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytoskeleton . Focal adhesion plaques and synapses (PubMed:12422219). .
Tissue expression
Brain,Epithelium,Skeletal muscle,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车