Molecular weight (DA)
110kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ROBO4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins.,similarity:Belongs to the immunoglobulin superfamily. ROBO family.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with SLIT2 and ENAH.,tissue specificity:Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.,
Function
function:Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins.,similarity:Belongs to the immunoglobulin superfamily. ROBO family.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with SLIT2 and ENAH.,tissue specificity:Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.,
Gene Name
ROBO4 UNQ421/PRO3674
Protein name
Roundabout homolog 4 (Magic roundabout)
Human protein sequence Database
Q8WZ75
Mouse protein sequence database
Q8C310
Rat protein sequence database
Q80W87
Cellular localization
integral component of membrane,extracellular exosome,
Tissue expression
Specifically expressed in endothelial cells. Expressed in endothelial and intimal cells of the ascending aorta (PubMed:30455415).
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